![]() dynamic hyperinflation if external PEPP > intrinsic PEEP.direct bronchodilation (PPV leads to increased FEV1 and PEFR in some studies). ![]() prevent atelectasis and maximise recruitment.PEEPi would otherwise need to be overcome by increased negative pleural pressure to initiate inspiration in a in a spontaneously breathing patient.occurs if external PEEP is set to match iPEEP in a spontaneously breathing patient.decreased work of breathing on inspiration.NIV has numerous possible advantages (see below) often requires neuromuscular blockers together with corticosteroids resulting in high risk of ICU-acquired weakness, and is associated with increased length of stay and mortality.Mechanical ventilation in asthma is difficult and has significant risks: part of a post-extubation strategy to prevent reintubation.pre-oxygenation and ventilatory support while preparing for intubation - can use with ketamine as part of a delayed sequence intubation (DSI) approach.to avoid intubation (improved gas exchange and avoidance of fatigue).improve rate of recovery and limit drug side effects (e.g.45: 227–243.Non-invasive ventilation (NIV) is widely used for severe asthma in Australasia yet remains a controversial topic The physiologic basis of pulmonary gas exchange: implications for clinical interpretation of arterial blood gases. Philadelphia: Lippincott Williams & Wilkins. In: Lippincott's Pathophysiology Series: Pulmonary Pathophysiology. “Gas transport to and from peripheral tissues”. In: Fishman's Pulmonary Diseases and Disorders, edited by MA, Grippi (editor-in-chief), JA, Elias, JA, Fishman, RM, Kotloff, AI, Pack, RM, Senior (editors). ![]() “Clinical presentations: gas exchange and transport”. ![]() ![]()
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